Verruciform xanthoma in the hard palate: a case report and literature review
Garcia Alexandre Simoes, Pagin Otavio, Santos Paulo Sergio da Silva, Oliveira Denise Tostes,
소속 상세정보
( Garcia Alexandre Simoes ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
( Pagin Otavio ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
( Santos Paulo Sergio da Silva ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
( Oliveira Denise Tostes ) - University of Sao Paulo Bauru School of Dentistry Department of Surgery, Stomatology, Pathology and Radiology
KMID : 0355620160420060383
Abstract
Oral verruciform xanthoma (OVX) is an uncommon lesion that appears on the oral mucosa. The aim of this paper was to discuss the probable etiopathogenesis of OVX in the hard palate, reinforcing the importance of including this lesion in the differential diagnosis of verrucous lesions. A 43-year-old male smoker presented with a painless lesion with a verrucous surface and erythematous spots on the hard palate. Excisional biopsy revealed oral mucosa consisting of hyperkeratosis, acanthosis, and elongated rete pegs. Subjacent connective tissue showed numerous foam cells with clear cytoplasm and pyknotic nucleus, negative on periodic acid-Schiff staining. Immunohistochemical analysis revealed foam cells positive for anti-CD68 antibody, while anti-KI-67 antibody was restricted to the basal layer of the oral epithelium. A final diagnosis of OVX was established. The patient showed no signs of recurrence after seven months of follow-up. Physical trauma and smoking habits can be directly related to the etiology of verruciform xanthoma because the lesion is chronic and inflammatory with slow growth, and sites if high trauma are more often affected by such a lesion. The hard palate is the second most commonly affected site, and local trauma caused by smoking can be a cause of this type of lesion.
키워드
Xanthomatosis; Hard palate; Immunohistochemistry
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